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精神分裂症患者工作记忆与执行功能表现关系的功能磁共振研究
作者: 任华 张云亭 张权 李威 张敬 沈建华 张新军 REN Hua ZHANG Yunting ZHANG Quan LI Wei ZHANG Jing SHEN Jianhua ZHANG Xinjun
单位:任华,REN Hua(中国中医科学院西苑医院放射科,北京,100091)张云亭,张权,李威,张敬,ZHANG Yunting,ZHANG Quan,LI Wei,ZHANG Jing(天津医科大学总医院放射科)沈建华,张新军,SHEN Jianhua,ZHANG Xinjun(天津安定医院)
关键词: 精神分裂症 执行功能表现 功能磁共振成像 工作记忆 正激活 负激活
分类号:
出版年·卷·期(页码):2009·35·第 8 期(0-0)
摘要:
目的 探讨偏执型精神分裂症患者2-back任务状态下的脑区激活特点及其与执行功能表现的关系.方法 采用参数性2-bsck任务,分别检测14例偏执型精神分裂症患者和16名正常志愿者的脑激活情况.应用SPM2软件进行图像数据处理,其中统计阈值P=0.005(未校正),对行为学表现采用SPSS13.0进行统计分析.结果在2-back任务时,患者组额顶叶正激活及负激活脑区的强度均低于正常对照组,但未见较正常对照组激活增强的脑区.行为学表现:患者组和对照组2-back任务的反应时间差异无统计学意义[(935.78±173.18)ms vs(845.16±101.07)ms,P>0.05],但患者组的反应正确率低于对照组[(78.30±8.76)%vs(89.89±8.05)%,P=0.01];患者组低于对照组的正激活脑区与患者组的反应正确率呈正相关(r为0.41~0.63),但只有右顶上小叶和右尾状核分别与正确率之间的相关有统计学意义(P<0.05);低于对照组的负激活脑区与患者组的反应正确率呈负相关但无统计学意义(r为-0.17~-0.35,P均大于0.05).结论 偏执型精神分裂症患者额顶叶正激活减弱与执行功能表现差有关;负激活减弱可能与执行功能表现差、注意转换效率低下或无效有关.
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