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中性内肽酶基因C159T多态性与阿尔茨海默病关联的初步研究
作者: 李爱凤 叶莉英 杨婵娟 唐牟尼 郭扬波 LI Aifeng YE Liying YANG Chanjuan TANG Mouni GUO Yangbo
单位:广州市精神病医院,广州,510370
关键词: Alzhermer病 中性内肽酶 载脂蛋白E 基因多态性
分类号:
出版年·卷·期(页码):2009·35·第 4 期(0-0)
摘要:
目的 观察中性内肽酶(neprilysin,NEP)C159T多态在广东地区汉族老年人中的分布,探讨其与晚发阿尔茨海默病(AD)的相关性.方法 以91例晚发AD患者和97名正常老年人为对照进行病例-对照研究.用聚合酶链反应-限制性片段长度多态性方法(PCR-RFLP)分析NEP基因C159T多态性和载脂蛋白E(apoE)基因多态性.结果 AD组C159T多态T等位基因频率较对照组降低(23.2%vs 25.3%,χ2=184.96,P0.05).AD组apoE等位基因ε4与AD成正关联(19.2%vs 8.2%,OR=2.648,χ2=9.66,P0.05).结论 NEP基因C159T多态C等位基因可能与晚发AD关联,未发现APOEε4与该多态性存在协同效应.
参考文献:
  • Iwata N.Tsubuki S.Takaki Y Identification of the major Abeta 1-42-degrading catabolic pathway in brain parenchyma:suppression leads to biochemical and pathological deposition 2000(02)
  • Shirotani K.Tsubuki S.lwata N Neprilysin degrades both amyloid beta peptides 1-40 and 1-42 most rapidly and efficiently among thiorphan-and phosphoramidon-sensitive endopeptidases 2001(24)
  • Sodeyama N.Mizusawa H.Yamada M Lack of association of neprilysin polymorphism with Alzheimer's disease and Alzheimer's disease-type neuropathological changes 2001(06)
  • Oda M.Morino H.Maruyama H Dinucleotide repeat polymorphisms in the neprilysin gene are not associated with sporadic Alzheimer's disease 2002(1-2)
  • Lilius L.Forsell C.Axelman K No association between polymorphisms in the neprilysin promoter region and Swedish Alzheimer's disease patients 2003(02)
  • Clarimon J.Munoz FJ.Boada M Possible increased risk for Alzheimer's disease associated with neprilysin gene 2003(06)
  • Sakai A.Ujike H.Nakata K Association of the Neprilysin gene with susceptibility to late-onset Alzheimer's disease 2004(03)
  • Tamura Y.Sakasegawa Y.Omi K Association study of the chemokine,CXC motif,ligand1 (CXCL1) gene with sporadic Alzheimer's disease in a Japanese population 2005(03)
  • Owen MJ.Cardno AG Psychiatric genetics:progress,problems,and potential 1999(zk)
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