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汉族人白细胞介素-6-174G/C基因多态性与颅内动脉瘤的关联性研究
作者: 张国忠 冯文峰 黄理金 刘晓军 王浩 郭志旺 漆松涛
单位:南方医科大学南方医院神经外科,广州,510515
关键词: 白细胞介素-6 颅内动脉瘤 基因多态性 限制性片段长度
分类号:
出版年·卷·期(页码):2009·35·第 4 期(0-0)
摘要:
目的 探讨汉族人白细胞介素-6-174G/C(IL-6-174G/C)基因多态性与颅内动脉瘤(IA)的相关性.方法 用聚合酶链反应-限制性片段长度多态性(PCR-RFLP)技术对182例颅内动脉瘤患者(颅内动脉瘤组)和182名健康者(对照组)的IL-6-174G/C的基因多态性进行分析,运用统计学方法分析基因与疾病的相关性.结果 IL-6-174G/C基因型的分布频率与对照组比较有统计学意义(P<0.001),IL-6-174(G/C)G等位基因频率为69.51%,对照组为56.87%,两组比较有统计学差异(P<0.001).结论 IL-6-174G/C基因多态性与颅内动脉瘤的发病有一定关系,考虑C等位基因频率增高与颅内动脉瘤的发病有关.
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