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高强度聚焦超声对裸鼠皮下人胶质瘤的治疗作用
作者: 肖文峰 霍钢 郑履平 唐文渊 孙晓川 支兴刚 李发琪 XIAO Wengfeng HUO Gang ZHENG Lvping TANG Wenyuan SHUN Xiaochuan ZHI Xinggang LI Faqi. Department of Neurosurgery The First Affiliated Hospital of Chongqing University of Medical Sciences 1 Yixueyuan Road Chongqing.400016.
单位:重庆医科大学附属第一医院神经外科; 重庆医科大学生物医学工程系 重庆;
关键词: 高强度聚焦超声 胶质瘤 有效性 交界区
分类号:
出版年·卷·期(页码):2008·34·第 4 期(0-0)
摘要:
目的通过研究高强度聚焦超声(high intensity focused ultrasound,HIFU)对裸鼠皮下人胶质瘤模型作用后的病理转归,探讨其治疗胶质瘤的有效性和安全性。方法选取24只裸鼠,建立裸鼠皮下人胶质瘤模型,随机分为对照组和实验组。用频率9.7MHz,焦距4.5mm,声强2500W/cm2的HIFU连续作用20s,于急性期(<3d)、亚急性期(4~14d)、慢性期(15~30d)观察各组肿瘤的生长情况;行2,3,5-三苯基氯化四氮唑(triphenyl tetrazoliumcholoride,TTC)染色、组织学切片及电镜检查。结果24只裸鼠全部成瘤,接种20d后肿瘤体积为(166.56&plusmn;9.23)mm3,在HIFU作用7d后,实验组肿瘤体积倍增时间(tumor volume doubling time,TD)与对照组差异有统计学意义(P<0.05)。TTC染色显示胶质瘤的生物学焦域为(66.12&plusmn;2.52)mm3。HE染色示照射区即刻就发生凝固性坏死,并随观察时间的延长坏死越明显;在亚急性期和慢性期可以观察到明显的交界区形成,且在照射区、交界区之间形成锐利的边界。电镜示细胞超微结构出现典...
Objective To explore the feasibility of high intensity focused ultrasound (HIFU) as a therapy for neurogliocytoma by assessing tumor regression of subcutaneous human neurogliocytoma xenografted in nude mice after ablation. Methods Twenty four nude mice bearing subcutaneous human neurogliocytoma xenografts were divided into control and experimental group randomly. An extracorporeal HIFU with 9.7 MHz transducer(the focal length of 4.5 mm and focal intensity 2500 W/cm2) was used in the experiments. The HIFU tr...
参考文献:

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