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貌似单纯疱疹病毒性脑炎的MELAS6例报告
作者: 卢岩 王向波 笪宇威 贾建平 孙高惠 王敏 袁泉 刘璐 LU Yan WANG Xiangbo DA Yuwei JIA Jianping SUN Gaohui WANG Min YUAN Quan LIU Lu. Department of Neurology Xuan Wu Hospital Capital Medical University Beijing 100053.
单位:首都医科大学宣武医院神经内科; 首都医科大学宣武医院神经内科 北京; 在读研究生;
关键词: MELAS 单纯疱疹病毒性脑炎 颅脑MRI
分类号:
出版年·卷·期(页码):2008·34·第 4 期(0-0)
摘要:
目的探讨线粒体脑肌病伴乳酸血症和卒中样发作(mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes,MELAS)的临床和影像特征,并与单纯疱疹病毒性脑炎(herpes simplex virus encephalitis,HSE)鉴别。方法回顾性分析6例临床表现酷似HSE的MELAS患者临床影像和病理资料。结果6例MELAS患者均因持续头痛、发热、癫痫样发作和智力下降被误诊为HSE;但还表现有视听力障碍、身材矮小、运动不耐受和(或)内分泌异常(糖尿病、甲状腺功能低下等),影像以大脑后半部颞枕顶叶皮层病灶为主,单侧或双侧受累,可与HSE鉴别,肌活检可见破碎红纤维。结论临床表现酷似HSE的病例,应与MELAS鉴别,确诊需肌活检。
Objective To investigate the characteristics of clinical manifestations and imaging of MELAS and to differentiate it from herpes simplex virus encephalitis (HSE). Methods The clinical,neuroradiologic and pathologic data of 6 cases of MELAS that masquerading as HSE were studied retrospectively. Results The main symptoms of six cases included persistent headache, fever, epileptic seizures and progressive mental impairment,which may lead to misdiagnosis as HSE. Besides these HSE-like symptoms, the patients als...
参考文献:

中国期刊全文数据库 共找到 2 条

[1] 吴磊,吴卫平,黄德晖,徐全刚,蒲传强. 误诊为单纯疱疹病毒性脑炎的MELAS综合征8例临床分析[J]. 临床神经病学杂志, 2006,(06) .
 
[2] 林洁,涂江龙,赵重波,汪寅,卢家红. 16例MELAS临床、神经影像与肌肉病理研究[J]. 中国神经精神疾病杂志, 2007,(07) .
 

西文参考文献 共找到 6 条

[1] Iizuka T,Sakai F,Suzuk i N,et al. Neuronal hyperexcitab ility instroke-like ep isodes of MELAS syndrom e[J] .Neurology. 2002, 59 :816 .
 
[2] Iizuka T,Sakai F,Kan S,et al. Slowly progressive spread of the stroke-like lesions in MELAS[J] .Neurology. 2003, 61 :1238-1244 .
 
[3] Karppa M,Syrjala P,Tolonen U,et al. Peripheral neuropathy in patients with the3243A>G mutation in mitochondrial DNA[J] .J Neurol, 2003, 250 (2) :216-221 .
 
[4] Hasegawa H,Matsuoka T,Goto Y,et al. Strongly succinate dehy-drogenase-reactive blood vessels in muscles from patients with mi-tochondrial myopathy,encephalopathy,lactic acidosis,and stroke-like episodes[J] .Ann Neurol, 1991, 29 (6) :601-605 .
 
[5] Abe K,Yoshimura H,Tanaka H,et al. Comparison of conven-tional and diffusion-weighted MRI and proton MR spectroscopy in patients with mitochondrial encephalomyopathy,lactic acidosis,and stroke-like events[J] .Neuroradiology, 2004, 46 (2) :113-117 .
 
[6] Lin CM,Thajeb P. Valproic acid aggravates Epilepsy due to MELAS in a patient with an A3243G mutation of mitochondrial DNA[J] .Metab Brain Dis, 2007, 22 (1) :105-109 .
 

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