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盐酸美金刚治疗阿尔茨海默病的临床研究
作者: 张楠 程焱 杜红坚 ZHANG Nan CHENG Yan DU Hongjian.Neurology Department Tianjin Medical University General Hospital 154 Anshan Road Heping District Tianjin 300052
单位:天津医科大学总医院; 天津医科大学总医院 天津;
关键词: 盐酸美金刚 盐酸多奈哌齐 阿尔茨海默病
分类号:
出版年·卷·期(页码):2008·34·第 1 期(0-0)
摘要:
目的与盐酸多奈哌齐对照比较盐酸美金刚治疗阿尔茨海默病(Alzheimer disease,AD)的有效性和安全性。方法将36例AD患者随机分为两组,采用双盲双模拟的方法,对照组给予盐酸多奈哌齐10mg/d,试验组给予盐酸美金刚20mg/d,疗程16周,每4周随访1次,评估简易精神状态量表(MMSE)、阿尔茨海默病评价量表-认知分量表(ADAS-cog)、日常生活能力量表(ADL)、临床疗效总评量表(CGI)、快速词汇测验(RVR)和数字广度测验(DS)。结果32例患者完成了本试验,盐酸多奈哌齐组MMSE、ADAS-cog、ADL、RVR和DS评分治疗前后比较均有统计学意义(P0.05)与治疗16周后两组评分比较(P>0.05),均无统计学差异。结论盐酸美金刚作为治疗AD的新药,可以改善AD患者的症状,疗效与盐酸多奈哌齐相当,且具有良好的安全性和耐受性。
Objective To evaluate the clinical efficacy and safety of akatinol memantine in the treatment of Alzheimer disease(AD).Methods 36 patients with AD were randomly assigned to receive 10 mg of donepezil daily or 20 mg of memantine daily for 16 weeks.The primary efficacy were evaluated by using the Mini-Mental Status Examination(MMSE),the Alzheimer Disease Assessment Scale-cognition(ADAS-cog)and the Activities of Daily Living(ADL).The secondary efficacy were evaluated by using the Clinical Global Impression(CGI...
参考文献:

中国期刊全文数据库 共找到 1 条

[1] 胡洪涛,张振馨,姚景莉,余慧贞,王荫华,汤洪川,冀成君,徐涛. 盐酸美金刚治疗阿尔茨海默病多中心随机对照临床试验[J]. 中华内科杂志, 2006,(04) .
 

西文参考文献 共找到 13 条

[1] Farlow MR. NMDA receptor antagonists:A new therapeutic ap-proach for Alzheimer s disease[J] .Geriatrics, 2004, 59 (6) :22-27 .
 
[2] Rosen WG, Mohs RC, Davis KL. A new rating scale for Alzheimer's disease .American Journal of Psychiatry. 1984, 141 :1356-1364 .
 
[3] Davis KL, Pollak WR, Pitney WP, et al. Cholinergic markers in elderly patients with early signs of Alzheimer disease .Journal of the American Medical Association, The. 1999, 281 :14011406 .
 
[4] Parsons CG, Danysz W, Quack G. Memantine is a clinically well tolerated N-methyl-D-aspartate (NMDA) receptor antagonist: a review of preclinical data .Neuropharmacology. 1999, 38 :735767 .
 
[5] McKhann G,Drachman D,Folstein M,et al. Clinical diagnosis of Alzheimer s disease:report of the NINCDS-ADRDA work group under the auspices of department of health and human services task force on Alzheimer s Disease[J] .Neurology, 1984, 34 (7) :939-944 .
 
[6] Lawton MP,Brody EM. Assessment of older people:self-maintai-ning and instrumental activities of daily living[J] .Gerontologist, 1969, 9 (3) :179-186 .
 
[7] Jon W,Shawn E. Mechanism of action of memantine[J] .Current Opinion in Pharmacology, 2006, 6 (1) :61-67 .
 
[8] Folstein MF,Folstein SE,McHugh PR. Mini-Mental State:a practical method for grading the cognitive state of patients for the clinician[J] .J Psychiatr Res, 1975, 12 (3) :189-198 .
 
[9] Rogawski MA,Wenk GL. The neuropharmacological basis for the use of memantine in the treatment of Alzheimer s disease[J] .CNS Drug Rev, 2003, 9 (3) :275-308 .
 
[10] Schmitt HP. On the paradox of ion channel blockade and its bene-fits in the treatment of Alzheimer disease[J] .Med Hypotheses, 2005, 65 (2) :259-265 .
 
[11] Reisberg B, Doody R, Stoffler A, et al. Memantine in moderatd-to-severe Alzheimer ' s disease .New England Journal of Medicine, The. 2003, 348(14) :1333-1341 .
 
[12] Reisberg B,Doody R,Stoffler A,et al. A24-week open-label ex-tension study of memantine in moderate to severe Alzheimer disease[J] .Arch Neurol, 2006, 63 (1) :49-54 .
 
[13] American psychiatric assosition. Diagnostic and statistical manual of mental disorders .4th ed. Washington: American Psychiat-ric Press, 1994, :147-154 .
 

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