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5-羟色胺转运体基因多态性与氟西汀疗效及副反应的关系
作者: 尹岩 刘盈 张慧杰 张英 王玥
单位:中国医科大学精神卫生教研室; 中南大学湘雅医学院附属第二医院精神卫生研究所; 沈阳师范大学; 中国医科大学第一附属医院门诊血液室;
关键词: 重性抑郁障碍 五羟色胺转运体 基因 多态性 氟西汀
分类号:
出版年·卷·期(页码):2008·34·第 12 期(0-0)
摘要:
目的探讨重性抑郁障碍(MDD)氟西汀疗效及不良反应与5-羟色胺转运体启动子区基因多态性(5-HTTLPR)的关系。方法选取符合美国精神障碍诊断与统计手册第4版(DSM-IV)重性抑郁障碍诊断标准的89例患者为研究对象。给予氟西汀治疗6周。利用聚合酶链反应(PCR)多态性技术检测5-HTTLPR多态性。结果不同基因型患者组之间治疗后HAMD总分减分率的差异有统计学意义(P<0.005),L/L基因型组的减分率高于另两种基因型组;有效组和无效组之间、有无恶心不良反应组之间的5-HTTL-PR的基因型和等位基因频率的差异均有统计学意义(P<0.05),L/L基因型组的疗效和恶心发生率高于另2组。结论5-HTTLPR基因多态性可能与氟西汀抗抑郁疗效及其恶心不良反应相关。
参考文献:

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