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负荷剂量氯吡格雷治疗非心源性急性脑梗死/短暂性脑缺血发作的预研究
作者: 杨万勇 徐安定 祁风 黄燕 余科 李又佳 谭泽锋 曾进胜 YANG Wanyong XU Anding QI Feng HUANG Yan YU Ke LI Youjia TAN Zefeng ZENG Jinsheng.Department of Neurology The First Affiliated Hospital of Jinan University Guangzhou 510630
单位:暨南大学脑科学研究所; 附属第一医院神经内科; 广州医学院荔湾医院神经内科; 广东省肇庆市第一人民医院神经内科; 中山大学附属第一医院神经内科;
关键词: 急性脑梗死/短暂性脑缺血发作 氯吡格雷 负荷剂量
分类号:
出版年·卷·期(页码):2008·34·第 11 期(0-0)
摘要:
目的初步评价负荷剂量氯吡格雷治疗非心源性急性脑梗死/短暂性脑缺血发作(transient ischemic attack,TIA)的可行性和安全性。方法前瞻性、多中心、随机对照、平行开放研究。起病48 h内入院的非心源性急性脑梗死/TIA患者,随机分为负荷剂量氯吡格雷组(首剂300 mg,之后75 mg·d-1)、标准剂量氯吡格雷组(75 mg·d-1),连用28 d。主要疗效指标:7 d内卒中进展或复发;主要安全指标:危及生命出血。结果3个研究中心共收集71例患者。与常规剂量组相比,负荷剂量氯吡格雷组7 d内卒中进展或复发相对危险度下降(RRR)55.8%(95%CI:-14.2%~82.9%),3个月时死亡或依赖RRR 35.2%(95%CI:-39.2%~69.8%),4周时有效率、3个月时良好预后率均显示负荷剂量组优于常规剂量组的优势。但所有比较均未达到统计学差异。结论:负荷剂量氯吡格雷治疗非心源性急性脑梗死/TIA有优于常规剂量氯吡格雷的趋势,未发现安全问题,值得进一步研究。
Objective To explore the feasibility and safety of loading dose of clopidogrel treatment in patients with non cardiaoembolic acute ischemic stroke / transient ischemic attack(TIA).Methods A multicenter,prospective,randomized,controlled parallel clinical trial was conducted to evaluate the feasibility and safety.Patients with non cardiaoembolic ischemic stroke or TIA within 48 h were randomized into load dose(300mg followed by daily 75 mg) or standard dose(daily 75 mg) clopidogrel group,respectively,and foll...
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