精神分裂症幻听患者汉语听觉语言皮质定位的脑磁图研究-中国神经精神疾病杂志

精神分裂症幻听患者汉语听觉语言皮质定位的脑磁图研究

单位：南京医科大学附属脑科医院精神科; 南京医科大学附属脑科医院脑磁图室; 江苏省淮安市第三人民医院精神科南京;

分类号：

出版年·卷·期（页码）：2008··第四期（225-228）

摘要：

目的采用脑磁图(MEG)技术探讨男性精神分裂症幻听患者汉语听觉语言皮质的定位。方法给予13例精神分裂症幻听患者和14名正常对照组双耳男、女声各100对词义相关及不相关的二个字汉语词汇刺激,并由MEG设备记录刺激后产生的听觉诱发磁场,将MEG采集数据叠加到核磁共振上获得磁源性影像。结果①患者组10例汉语听觉语言皮质定位在大脑半球双侧颞中、上回后部、额下回后部,2例在右侧额下回后部,1例在左侧颞上回后部。对照组10名定位于左侧颞中、上回后部,即Wernicke区,2名定位于右侧颞中回后部,2名定位在双侧颞上回后部。患者组定位在双侧比例明显高于对照组(76.92%vs14.29%,2=2.88,P<0.05)。②无论男声或女声刺激,患者组与对照组的中枢三维坐标在X轴上差异均有统计学意义(P<0.05)。结论精神分裂症幻听患者的汉语语言皮质定位与正常人的位置不同,更靠近颞中、上回外侧部,这一改变可能是其听觉性语言认知功能障碍的神经病理学基础之一。

Objective To localize Chinese linguistic auditory cortex in schizophrenic patients with auditory hallucination using MEG. Methods Thirteen male schizophrenic patients with auditory hallucination (study group) and 14 healthy people (control group) were given 100 pairs of two Chinese words stimuli (containing 80 percent related words) produced by both male and female speakers. The data acquired by the MEG were superimposed on magnetic resonance imaging (MRI) to obtain magnetic source imaging (MSI). Results ① ...

参考文献：

中国期刊全文数据库共找到 3 条

[1]	张玉梅,文永霞,张宁,孙海欣,王拥军. 母语为汉语者听觉性语言中枢的定位[J]. 首都医科大学学报, 2006,(05) .
[2]	孙吉林,吴杰,李素敏,吴晶,赵华东,吴育锦,刘连祥. 磁源性影像对母语为汉语者语言皮质定位的研究[J]. 中华放射学杂志, 2003,(04) .
[3]	吴文,王一牛,邓圣君. 运动性失语症患者听觉通道语言加工的功能性磁共振特征[J]. 中国临床康复, 2006,(06) .

西文参考文献共找到 9 条

[1]	Simos PG, Papanicolaou AC, Breier JI, et al. Localization of language-specific cortex by using magnetic source imaging and electrical stimulation mapping .Journal of Neurosurgery. 1999, 91 :787-796 .
[2]	Tollefson GD. Cognitive function in schizophrenic patients[J] .J Clin Psychiatry, 1996, 57 (1) :31-42 .
[3]	Tiitinen H,Salminen NH,Palomaki KJ,et al. Neuromagnetic re-cordings reveal the temporal dynamics of auditory spatial processing in the human cortex[J] .Neuroscience Letters, 2006, 396 (1) :17-22 .
[4]	Blasi V,Young AC,Tansy AP,et al. Word retrieval learning modu-layes right frontal cortex in patients with left frontal damage[J] .Neuron, 2002, 36 (1) :159-170 .
[5]	Kasai K,Yamada H,Kamio S,et al. Neuromagnetic correlates ofimpaired automatic categorical perception of speech sounds in schizophrenia[J] .Schizophr Res, 2003, 59 (2-3) :159-172 .
[6]	Goldman-Rakic PS,Castner SA,Svensson TH,et al. Targeting the dopamine D1receptor in schizophrenia:insights for cognitive dys-function[J] .Psychopharmacology(Berl), 2004, 174 (1) :3-16 .
[7]	Kircher TT,Rapp A,Grodd W,et al. Mismatch negativity responses in schizophrenia:a combined fMRI and whole-head MEG study[J] .Am J Psychiatry, 2004, 161 (2) :294-304 .
[8]	Bowyer SM,Moran JE,Mason KM,et al. MEG localization of lan-guage-specific cortex utilizing MR-FOCUSS[J] .Neurology, 2004, 62 (12) :2247-2255 .
[9]	Ojemann G,Ojemann J,Lettich E,et al. Cortical language localiza-tion in left,dominant hemisphere[J] .J Neurosurg, 1989, 71 (3) :316-326 .

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