垂体腺瘤PTTG和Ki-67表达与其海绵窦下方间隙生长的关系-中国神经精神疾病杂志

垂体腺瘤PTTG和Ki-67表达与其海绵窦下方间隙生长的关系

单位：山东省立医院神经外科; 山东省立医院病理科; 山东省立医院病理科烟台市烟台山医院神经外科;

分类号：

出版年·卷·期（页码）：2008··第一期（37-39）

摘要：

目的研究有海绵窦下方静脉间隙侵袭的垂体瘤组织的免疫组化特性,了解其对于垂体瘤侵袭性预测的意义。方法对我院2005~2006年行手术治疗的有海绵窦侵袭的垂体瘤患者资料根据有没有海绵窦下方间隙侵袭进行分组,并对不同组别标本行免疫组化Ki-67和PTTG检查。结果96例患者中有海绵窦下方间隙侵袭者40例,其中Ki-67高表达者32例,PTTG高表达者为30例,无海绵窦段颈内动脉下方侵袭者56例,其中Ki-67高表达者24例,PTTG高表达者为18例,经检验发现肿瘤有海绵窦下方间隙侵袭者其PTTG和Ki-67的表达率与没有海绵窦下方间隙侵袭者的表达率差异有统计学意义。结论垂体腺瘤有海绵窦下方间隙生长者细胞增殖能力较强,肿瘤易复发,应给予术后放射治疗或是药物治疗。

参考文献：

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[1]	潘力雄,刘运生,陈忠平. 垂体瘤侵袭性与细胞增殖周期核抗原Ki-67表达的关系[J]. 中华实验外科杂志, 2001,(03) .
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