磷脂酰肌醇-3激酶在人骨骼肌纤维的表达

作者：赵清石  江新梅  胡静  鞠浩  袁军辉

单位：吉林大学第一医院神经内科; 河北医科大学第三医院神经肌病实验室; 河北医科大学第三医院神经肌病实验室 长春;

关键词：磷脂酰肌醇-3激酶  肌纤维再生  骨骼肌活检  神经细胞粘附分子  结蛋白

分类号：

出版年·卷·期（页码）：2008··第一期（35-37）

摘要：

目的研究磷脂酰肌醇-3激酶在肌病患者骨骼肌纤维的表达及其意义。方法选择Duchenne型肌营养不良(Duch-enne muscular dystrophy,DMD)9例、Becker假肥大型肌营养不良(Becker muscular dystrophy,BMD)6例、先天性肌营养不良(congenital muscular dystrophy,CMD)3例、多发性肌炎(polymyositis,PM)5例,开放式骨骼肌活检,连续冰冻切片,苏木精-伊红(hematoxylin and eosin,HE)、三磷酸腺苷酶(adenosin triphosphatase,ATPase)组织化学染色;抗-磷脂酰肌醇-3激酶(phosphatidylinositol 3-kinase,PI3K)、抗-神经细胞粘附分子(neural cell adhesion molecule,NCAM)、抗-结蛋白(desmin)单克隆抗体免疫组织化学染色,病理分析。结果①PI3K在再生早期小径肌纤维膜上表达,伴随再生肌纤维的成熟PI3K表达消失;②PI3K在幼儿肌纤维膜上表达显著;③PI3K在动静脉平滑肌上表达显著。结论PI3K可能...

参考文献：

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